From Dr. Mercola:
Of course, they [the artificial sweetener manufacturers] claim these are "three smart new ways to sweeten" your food and drink. Nothing could be further from the truth. In fact, it's sheer unmitigated nonsense! Splenda (sucralose), which is an artificial sweetener like aspartame, is likely to push your health in the wrong direction, and there's nothing smart about that…Listen to Dr. Mercola's report here:
Consuming artificial sweeteners can cause distortions in your biochemistry, and if you drink diet soda in an attempt to lose weight, they won't help you. Instead, most studies looking at this show very clearly that diet soft drinks actually double your obesity risk by stimulating your appetite, increasing carbohydrate cravings, and stimulating fat storage!